Many prostate cancers relapse due to the generation of chemoresistance rendering first-line treatment drugs like paclitaxel (PTX) ineffective.The present study aims to determine the role of miRNAs and Hedgehog (Hh) pathway in chemoresistant prostate cancer and to evaluate the combination therapy using Hh inhibitor cyclopamine (CYA).Studies were con

The maintenance of a high delivery efficiency by traditional nanomedicines during cancer treatment is a challenging task.As a natural mediator for short-distance intercellular communication, extracellular vesicles (EVs) have garnered significant attention owing to their low immunogenicity and high targeting ability.They can load a variety of major

With the development of artificial intelligence, machine learning algorithms and deep learning algorithms are widely applied to attack detection models.Adversarial attacks against artificial intelligence models become inevitable problems when there is a lack of research on the cross-site scripting (XSS) attack detection model for defense against at

The impact of UV radiation on the high-temperature behavior of polyphenylene sulfide (PPS) fiber was investigated in this study.The ultimate strength, failure strain elasticity modulus and toughness were employed to evaluate the degradation caused by the coupling effects of UV radiation and high temperature.The degradation characteristics of PPS fi

The activities in the 2006-2007 austral summer of the 48th Japanese Antarctic Research Expedition (JARE-48) are reported.JARE-48 consisted of 62 personnel including 27 summer personnel and 35 wintering personnel.In addition, several observers joined to the voyage of Icebreaker Shirase (four Japanese), operation at Dome Fuji Station (two foreigners)